Our expertise and laboratory to develop your distillation processes.

Distillation processes


In brief

Processium has the tools and skills to develop full distillation processes. From acquiring thermodynamic data, modeling, simulation and optimization to experimental validation, Processium has developed a robust, recognized methodology to scale up distillation processes.


  • Acquisition and modeling of thermodynamic properties (vapor pressure, phase equilibria, activity coefficients, and more);
  • Simulation of batch, semi-batch or continuous distillation processes, coupling with other unit operations, energy integration and more;
  • Experimental validation at laboratory or pilot scale;
  • Choice of technologies, sizing and economic estimates;
  • Support in working with an equipment supplier.

Processium also works on complex or innovative distillation processes, such as reactive, azeotropic, divided-wall or side-draw distillation.

Our tools


Third-party and in-house tools enable our engineers to model and simulate distillation processes to optimize quality, yields and costs. Processium has the following tools:

  • Aspen Plus;
  • Aspen batch distillation;
  • ProSim;
  • and others.

Over the years, Processium has acquired specific expertise in simulating complex distillation processes involving recycling, energy integration, side-draws, etc.


Processium utilizes a range of tools to acquire precise thermodynamic data, including phase equilibria, vapor pressures, infinite dilution activity coefficients, and more. We have the following tools:

  • Static or dynamic liquid-vapor measurement devices, equipped with online samplers;
  • Ebulliometer;
  • Exponential dilutor.

Measurements can be performed on wide pressure and temperature ranges, from -20 °C to 280°C, and from 0.1 mbar to 100 bars.

Distillation units

Experimental validation is carried out at Processium’s process laboratory, on laboratory-sized units when our customers have little product, or on pilot-sized units that can process dozens of kilograms. We utilize the following tools:

  • Batch vacuum and high-pressure distillation;
  • Continuous vacuum, cryogenic and high-pressure distillation.

Distillation can be performed over wide pressure and temperature ranges, from -20°C to 250°C, and from 1 mbar to 20 bars. L’efficacité de nos colonnes est ajustable jusqu’à 45 étages théoriques.

Example completed projects

Example completed projects

Sizing & experimental validation of a cryogenic & pressure swing distillation process

Debottlenecking of a batch extractive distillation process

Optimization of a process to purify a pharmaceutical ingredient

Sizing of a heteroazeotropic distillation dehydration unit

Design & sizing of a heterogeneous reactive distillation process


Our laboratory equipment.

We use a wide range of laboratory and pilot equipment to provide our services.



Our services to support your project.

Discover our range of services to support you in developing your processes.